ChondroPlex is a combination of GlucosaGreen glucosamine and CS BioActive chondroitin for joint health, along with OptiMSM. This product provides clinically trialled doses of glucosamine and chondroitin to help relieve symptoms of mild osteoarthritis of the knee including mild joint swelling, pain, reduced mobility, cartilage wear and narrowing joint space.

• Glucosamine sulfate sodium chloride - GlucosaGreen 628.1 mg (glucosamine sulfate 500 mg)
• Bovine sodium chondroitin sulfate - CS BioActive 293.8 mg (chondroitin sulfate) 267 mg
• Dimethyl sulfone OptiMSM 400 mg

Adults: Take 1 tablet three times a day, or as professionally prescribed.

If you are pregnant or breastfeeding, talk to your health professional before use.

Contains 240 mg of sodium per daily dose.

Contains sulfites.

Taking glucosamine supplementation long-term (>3 years) can lower plasma glucose levels in patients with osteoarthritis. Patients with diabetes or hypoglycaemia should be monitored.

However, clinical research suggests that various forms of glucosamine do not have adverse effects on blood glucose or haemoglobin A1C (HbA1C) in healthy, obese patients with type 2 diabetes or impaired glucose tolerance.

Taking glucosamine sulfate for up to 3 years does not significantly increase blood glucose or lipid levels, or cause any other disturbances in metabolism.

Due to theoretical anticoagulant activity of chondroitin, caution is advised in people with clotting disorders.

Although haematological changes have not occurred in patients taking chondroitin sulfate in clinical trials, patients undergoing anticoagulant therapy should have their blood clotting monitored.

Avoid combination -

Glucosamine: Warfarin - Anticoagulants, antithrombotics

Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database

Concomitant use of glucosamine may potentiate the effect of warfarin.

Warfarin side effects: Watch for dangerous interactions.

Possible augmentation of warfarin effect by glucosamine-chondroitin.

Glucosamine sulfate in the treatment of knee osteoarthritis symptoms:

Caution

Glucosamine: Hypoglycaemic agents

The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial.

Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial.

Inconclusive -

Glucosamine: Antibiotic cytotoxics

Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II.

Speculative -

Glucosamine: Paracetamol- Simple analgesics and antipyretics

Antinociceptive synergy, additivity, and subadditivity with combinations of oral glucosamine plus nonopioid analgesics in mice.

Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey.