Migraine Care includes vitamin B2 to help reduce the occurrence of mild migraines. Vitamin B6 and magnesium support a healthy stress response in the body when dietary intake is inadequate. Vitamin B6 also assists in the synthesis of neurotransmitters, with magnesium and B vitamins supporting nervous system function. Co-enzyme Q10, B vitamins and magnesium support energy production.

• Riboflavin (vitamin B2) 200 mg
• Pyridoxine hydrochloride 15.19 mg (equiv. to pyridoxine (vit B6) 12.5 mg)
• Calcium folinate 347.2 micrograms (equiv. to folinic acid (activated vitamin B9) 250 micrograms)
• Cyanocobalamin (vitamin B12) 200 micrograms
• Magnesium (as magnesium citrate) 150 mg
• Ubidecarenone (co-enzyme Q10) 75 mg
• Tanacetum parthenium (feverfew) herb 40 mg (min. equiv. to dry 280 mg, std. to parthenolide 200 micrograms)

Adults: Take 1 tablet two times a day, or as professionally prescribed.

Do not use during pregnancy or breastfeeding.

Do not take while on warfarin therapy without medical advice.

Contains sulfites.

anacetum parthenium should not be used in pregnancy.

Do not prescribe Tanacetum parthenium alongside NSAIDs; it may have adverse effects.

People taking medicine to prevent or treat blood clots should talk to their doctor before taking Tanacetum parthenium; it may increase the risk of bleeding.

Theoretically, Tanacetum parthenium may increase levels of drugs metabolised by CYP P450 enzymes.

People with cancer, anxiety or narcolepsy should talk to their doctors before taking vitamin B6; it may interact with their medicines.

Vitamin B6 should not be used in high doses (>100 mg) long-term, as this can induce toxicity.

Concurrent use of anti-seizure medications with vitamin B6 should be monitored.

Vitamin B12 may reduce tetracycline hydrochloride (antibiotic) bioavailability; separate doses by at least two hours.

Magnesium supplementation is contraindicated in renal failure and heart block, and should be used cautiously in people with compromised renal function.

Observe patients on warfarin taking CoQ10 dosing higher than 100 mg; an increase in minor bleeding events may occur.

Caution with CoQ10 and hypotension/hypertension; may lower blood pressure and can have additive effects with antihypertensive drugs.

Avoid combination -

Magnesium: Alendronate - Agents affecting calcium and bone metabolism

TGA Online Product Information: Alendronate

Magnesium: Ciprofloxacin - Quinolones

Reduced enteral absorption of ciprofloxacin in the presence of antacids.

Magnesium: Clodronate - Agents affecting calcium and bone metabolism

TGA Online Product Information: Clodronate

Magnesium: Demeclocycline - Tetracyclines

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid.

Magnesium: Doxycycline - Tetracyclines

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid.

Magnesium: Etidronate - Agents affecting calcium and bone metabolism

TGA Online Product Information: Etidronate

Magnesium: Ibandronic acid - Agents affecting calcium and bone metabolism

TGA Online Product Information: Ibandronic acid

Magnesium: Minocycline - Tetracyclines

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid.

Magnesium: Moxifloxacin - Quinolones

Evaluation of the influence of antacids and H2 antagonists on the absorption of moxifloxacin after oral administration of a 400mg dose to healthy volunteers.

Magnesium: Norfloxacin - Quinolones

Norfloxacin interaction with antacids and minerals.

Pharmacokinetic interactions of norfloxacin with some metallic medicinal agents.

Magnesium: Penicillamine - Antirheumatoid agents

Reduction in oral penicillamine absorption by food, antacid, and ferrous sulfate.

Magnesium: Proguanil - Antimalarials

The effect of magnesium trisilicate on proguanil absorption.

Magnesium: Risedronate - Agents affecting calcium and bone metabolism

TGA Online Product Information: Risedronate

Magnesium: Tetracycline - Tetracyclines

Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid.

Magnesium: Tiludronate - Agents affecting calcium and bone metabolism

TGA Online Product Information: Tiludronate

Skelid (tiludronate disodium) Prescribing Information.

Caution -

Coenzyme Q10: Warfarin - Anticoagulants, antithrombotics

Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial

Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: a longitudinal analysis

Folate: Phenytoin - Anticonvulsants

Influence of folic acid on blood-phenytoin levels.

Phenytoin and folic acid interaction: a preliminary report.

Phenytoin and folic acid: individualized drug-drug interaction.

Folic acid improves phenytoin pharmacokinetics.

Phenytoin-folic acid interaction.

Folate: Warfarin - Anticoagulants, antithrombotics

Effects of folic acid supplementation on the pharmacokinetics and anticoagulant effect of warfarin: an open-label, prospective study of long-term administration in adults.

Magnesium: Amikacin - Aminoglycosides

Potentiation of magnesium sulfate-induced neuromuscular weakness by gentamicin, tobramycin, and amikacin.

Magnesium: Chlorpromazine - Antipsychotic agents

Chlorpromazine: effects of antacids on its gastrointestinal absorption.

Magnesium: Gentamicin - Aminoglycosides

Potentiation of magnesium sulfate-induced neuromuscular weakness by gentamicin, tobramycin, and amikacin.

Magnesium: Nitrofurantoin - Other antibiotics and anti-infectives

Effect of magnesium trisilicate on nitrofurantoin absorption.

Magnesium: Tobramycin - Aminoglycosides

Potentiation of magnesium sulfate-induced neuromuscular weakness by gentamicin, tobramycin, and amikacin.

Vitamin B6: Levodopa - Movement disorders

Pyridoxine reversal of L-dopa effects in Parkinsonism.

Failure of vitamin B6 to reverse the L-dopa effect in patients on a dopa decarboxylase inhibitor.

Vitamin B6: Phenobarbitone - Anticonvulsants

Pyridoxine and serum concentration of phenytoin and phenobarbitone.

Vitamin B6: Phenytoin - Anticonvulsants

Pyridoxine and serum concentration of phenytoin and phenobarbitone.

Speculative -

Feverfew: Anticoagulants, antithrombotics

WHO monographs on selected medicinal plants. Volume 2

Potential interactions between alternative therapies and warfarin.

Feverfew-an antithrombotic drug

Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups.

Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes.